Our group aims to understand the mechanisms leading to loss of bone tissue integrity and to abnormal calcification of soft tissues in humans and mice. Accordingly, our research projects focus on the cellular and molecular mechanisms involved in skeletal formation and mineralization, the interaction between bone and other skeletal tissues, and the role of phosphate sensing. The ultimate goal is to identify novel strategies for fracture prevention, fracture healing and bone regeneration, and be able to counteract the deleterious effect of phosphate in pathophysiological conditions such as chronic kidney disease.
We recently obtained an ANR funding entitled « Phosphate and vascular calcifications in chronic kidney disease » (PARKA project) whom overall objective is to uncover the mechanism of action of Pi resulting in the development of vascular calcifications in the context of CKD, and identify putative therapeutic targets capable of counteracting its deleterious effects.
To explore these topics, we are deciphering the roles and mechanisms of action of PiT1 and PiT2 proteins in the skeleton and related tissues using genetic approaches in mice. PiT1 and PiT2 were originally described as phosphate transporters, but we have shown that they are in fact multifunctional proteins. Exploring the physiology and pathophysiology of the skeleton through the study of PiT’s mechanisms of action brings us to study both phosphate-related and unrelated phenomenons.
NanoCT of a mouse femur showing the bone microarchitecture (white) and the bone marrow adiposity (red).
Our current work further explores the role of PiT1 and PiT2 in particular physiological and pathophysiological situations.
We focus on deciphering their roles and their mechanism of action in the interaction between bone and other skeletal tissues (vessels and bone marrow adiposity), as well as the sensing of phosphate in vascular calcification and other cardiovascular diseases.
NanoCT reconstruction of a mouse femur showing the bone microarchitecture (white) and the bone vessels (red).